animal models of focal brain ischemia局部脑缺血的动物模型.pdfVIP

Experimental Translational Stroke Medicine BioMed Central Review Open Access Animal models of focal brain ischemia Kenneth M Sicard and Marc Fisher* Address: Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01453, USA Email: Kenneth M Sicard - sicardk@; Marc Fisher* - fisherm@ * Corresponding author Published: 13 November 2009 Received: 16 July 2009 Accepted: 13 November 2009 Experimental Translational Stroke Medicine 2009, 1:7 doi:10.1186/2040-7378-1-7 This article is available from: /content/1/1/7 © 2009 Sicard and Fisher; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Stroke is a leading cause of disability and death in many countries. Understanding the pathophysiology of ischemic injury and developing therapies is an important endeavor that requires much additional research. Animal stroke models provide an important mechanism for these activities. A large number of stroke models have been developed and are currently used in laboratories around the world. These models are overviewed as are approaches for measuring infarct size and functional outcome. Utility of Animal Models of Ischemic