原创力文档antimicrobial management and appropriateness of treatment of urinary tract infection in general practice in ireland抗菌药物管理和适当的治疗尿路感染的一般实践在爱尔兰.pdfVIP
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antimicrobial management and appropriateness of treatment of urinary tract infection in general practice in ireland抗菌药物管理和适当的治疗尿路感染的一般实践在爱尔兰
Vellinga et al. BMC Family Practice 2011, 12:108
/1471-2296/12/108
RESEARCH ARTICLE Open Access
Antimicrobial management and appropriateness
of treatment of urinary tract infection in general
practice in Ireland
1* 2,3 2 4 1
Akke Vellinga , Martin Cormican , Belinda Hanahoe , Kathleen Bennett and Andrew W Murphy
Abstract
Background: Urinary tract infections (UTIs) are the second most common bacterial infections in general practice
and a frequent indication for prescription of antimicrobials. Increasing concern about the association between the
use of antimicrobials and acquired antimicrobial resistance has highlighted the need for rational pharmacotherapy
of common infections in general practice.
Methods: Management of urinary tract infections in general practice was studied prospectively over 8 weeks.
Patients presenting with suspected UTI submitted a urine sample and were enrolled with an opt-out methodology.
Data were collected on demographic variables, previous antimicrobial use and urine samples. Appropriateness of
different treatment scenarios was assessed by comparing treatment with the laboratory report of the urine sample.
Results: A total of 22 practices participated in the study and included 866 patients. Bacteriuria was established for
21% of the patients, pyuria without bacteriuria for 9% and 70% showed no laboratory evidence of UTI. An
antimicrobial agent was prescribed to 56% (481) of the patients, of whom 33% had an isolate, 11% with pyuria
only and 56% without laboratory evidence of UTI. When taking all patients into account, 14% patients had an
isolate identified and were prescribed an antimicrobial to which the isolate was susceptible. The agents most
commonly prescr
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