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analysis of the distribution of functionally relevant rare codons分析功能相关的稀有密码子的分布
BMC Genomics BioMed Central
Research article Open Access
Analysis of the distribution of functionally relevant rare codons
1 2 2 1
Michael Widmann , Marie Clairo , Jürgen Dippon and Jürgen Pleiss*
Address: 1Institute of Technical Biochemistry, Allmandring 31, 70569 Stuttgart, Germany and 2Institut für Stochastik und Anwendungen,
Pfaffenwaldring 57, 70569 Stuttgart, Germany
Email: Michael Widmann - Michael.Widmann@itb.uni-stuttgart.de; Marie Clairo - Marie.Clairo@mines.inpl.nancy.fr;
Jürgen Dippon - Juergen.Dippon@mathematik.uni-stuttgart.de; Jürgen Pleiss* - Juergen.Pleiss@itb.uni-stuttgart.de
* Corresponding author
Published: 5 May 2008 Received: 15 February 2008
Accepted: 5 May 2008
BMC Genomics 2008, 9:207 doi:10.1186/1471-2164-9-207
This article is available from: /1471-2164/9/207
© 2008 Widmann et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: The substitution of rare codons with more frequent codons is a commonly applied
method in heterologous gene expression to increase protein yields. However, in some cases these
substitutions lead to a decrease of protein solubility or activity. To predict these functiona
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