application of amino acid occurrence for discriminating different folding types of globular proteins应用氨基酸发生歧视不同的折叠类型的球状蛋白.pdfVIP

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application of amino acid occurrence for discriminating different folding types of globular proteins应用氨基酸发生歧视不同的折叠类型的球状蛋白.pdf

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application of amino acid occurrence for discriminating different folding types of globular proteins应用氨基酸发生歧视不同的折叠类型的球状蛋白

BMC Bioinformatics BioMed Central Methodology article Open Access Application of amino acid occurrence for discriminating different folding types of globular proteins Y-h Taguchi* 1,2 and M Michael Gromiha*3 Address: 1Department of Physics, Faculty of Science and Technology, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan, 2Institute for Science and Technology, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan and 3Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), AIST Tokyo Waterfront Bio-IT Research Building, 2-42 Aomi, Koto-ku, Tokyo 135-0064, Japan Email: Y-h Taguchi* - tag@; M Michael Gromiha* - michael-gromiha@aist.go.jp * Corresponding authors Published: 22 October 2007 Received: 1 June 2007 Accepted: 22 October 2007 BMC Bioinformatics 2007, 8:404 doi:10.1186/1471-2105-8-404 This article is available from: /1471-2105/8/404 © 2007 Taguchi and Gromiha; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Predicting the three-dimensional structure of a protein from its amino acid sequence is a long-standing goal in computational/molecular biology. The discrimination of different structural classes and folding types are intermediate steps in protein structure predicti