association between hla-drb1 alleles polymorphism and hepatocellular carcinoma a meta-analysishla-drb1等位基因多态性与肝细胞癌的荟萃分析.pdfVIP

Lin et al. BMC Gastroenterology 2010, 10:145 /1471-230X/10/145 RESEARCH ARTICLE Open Access Association between HLA-DRB1 alleles polymorphism and hepatocellular carcinoma: a meta-analysis 1,2† 2,3† 2 2 2 2 Zhong-Hua Lin , Yong-Ning Xin , Quan-Jiang Dong , Qing Wang , Xiang-Jun Jiang , Shu-Hui Zhan , Ying Sun2, Shi-Ying Xuan2,3* Abstract Background: HLA-DRB1 allele polymorphisms have been reported to be associated with hepatocellular carcinoma susceptibility, but the results of these previous studies have been inconsistent. The purpose of the present study was to explore whether specific HLA-DRB1 alleles (DRB1*07, DRB1*12, DRB1*15) confer susceptibility to hepatocellular carcinoma. Methods: Case-control studies on HLA-DRB1 alleles association with HCC were searched up to January 2010 through a systematic review of the literature. The odds ratios (ORs) of HLA-DRB1 allele distributions in patients with hepatocellular carcinoma were analyzed against healthy controls. The meta-analysis software REVMAN 5.0 was applied for investigating heterogeneity among individual studies and for summarizing all the studies. Meta-analysis was performed using fixed-effect or random-effect methods, depending on absence or presence of significant heterogeneity. Results: Eight case-control studies were included in the final analysis. Among the 3 HLA-DRB1 alleles studied, DRB1*07 and DRB1*12 were significantly associated with the risk of HCC in the whole populations (OR = 1.65, 95% CI: 1.08-2.51, P = 0.02 and OR = 1.59, 95% CI: 1.09-2.32, P = 0.02, respectively). No significant association was established for DRB1*15 allele with HCC in the whole populations. Subgroup analysis by ethnicity showed that DRB1*07, DRB1*