association between lrp5 polymorphism and bone mineral density a bayesian meta-analysislrp5多态性与骨密度之间的关系一个贝叶斯荟萃分析.pdfVIP

BMC Medical Genetics BioMed Central Research article Open Access Association between LRP5 polymorphism and bone mineral density: a Bayesian meta-analysis 1 1 1,2 Bich NH Tran , Nguyen D Nguyen , John A Eisman and Tuan V Nguyen* 1,2 Address: 1Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincents Hospital, Sydney, Australia and 2Faculty of Medicine, The University of New South Wales, Sydney, Australia Email: Bich NH Tran - b.tran@.au; Nguyen D Nguyen - n.nguyen@.au; John A Eisman - j.eisman@.au; Tuan V Nguyen* - t.nguyen@.au * Corresponding author Published: 27 June 2008 Received: 25 February 2008 Accepted: 27 June 2008 BMC Medical Genetics 2008, 9:55 doi:10.1186/1471-2350-9-55 This article is available from: /1471-2350/9/55 © 2008 Tran et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The low-density lipoprotein receptor-related protein 5 gene (LRP5) was identified to be linked to the variation in BMD in high bone mass pedigrees. Subsequent population-based studies of the association between the LRP5 gene and BMD have yielded conflicting results. The present study was aimed at examining the association be