atrial fibrillation in aortic stenosis - echocardiographic assessment and prognostic importance心房纤维性颤动在主动脉瓣狭窄-超声心动图评估和预后的重要性.pdfVIP

Burup Kristensen et al. Cardiovascular Ultrasound 2012, 10:38 /content/10/1/38 CARDIOVASCULAR ULTRASOUND RESEARCH Open Access Atrial fibrillation in aortic stenosis - echocardiographic assessment and prognostic importance 1* 1 1 1 2 Charlotte Burup Kristensen , Jan Skov Jensen , Peter Sogaard , Helle Gervig Carstensen and Rasmus Mogelvang Abstract Background: Atrial fibrillation (AFib) exists more frequently in patients with aortic stenosis (AS) than in patients without, and AFib may be a sign of progressive deterioration of AS. Echocardiographic assessment of AS in sinus rhythm is well documented, however, little is known about AFib in AS since such patients often are excluded from clinical echocardiographic trials. Aim: The purpose of this study was to assess the prognostic importance of AFib in AS. Methods: The study was designed as a single-center case-control study. Patients with AS and AFib were enrolled as cases (n = 103) and subsequently matched to controls (103 patients with AS but sinus rhythm). Cases and controls were matched according to age, gender and severity of AS. Primary outcome was all cause mortality and follow-up was 100% complete. Results: Compared to controls the group with AFib had lower mean ejection fraction (42% vs. 49%; p 0.001) and stroke volume (47 mL vs. 55 mL; p = 0.004), but higher heart rate (81 bpm vs. 68 bpm; p 0.001) and no significant difference with regard to cardiac output (3.8 L vs. 4.