原创力文档gastrin-releasing peptide, substance p and cytokines in rheumatoid arthritis胃泌素释放肽、p物质和细胞因子在类风湿性关节炎.pdfVIP
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gastrin-releasing peptide, substance p and cytokines in rheumatoid arthritis胃泌素释放肽、p物质和细胞因子在类风湿性关节炎
Available online /contents/7/3/111
Commentary
Gastrin-releasing peptide, substance P and cytokines in
rheumatoid arthritis
Paul G Green
Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, CA, USA
Corresponding author: Paul G Green, paul@
Published: 30 March 2005 Arthritis Research Therapy 2005, 7:111-113 (DOI 10.1186/ar1746)
This article is online at /content/7/3/111
© 2005 BioMed Central Ltd
See related research by Grimsholm et al., /content/7/3/R416
Abstract they observed a significant correlation between the levels of
Many studies have shown that modulation of cytokine function is just two neuropeptides, bombesin/gastrin-releasing peptide
effective in ameliorating symptoms of rheumatoid arthritis. Neuro- (BN/GRP) and substance P (SP) with inflammatory cytokines.
peptides have recently been shown to have powerful effects on the
production and release of cytokines and have also been shown to It is well known that proinflammatory cytokines have a
exert potent proinflammatory and anti-inflammatory effects in fundamental role in the development and maintenance of RA
animal models of inflammatory diseases. An analysis of cytokine
and other inflammatory diseases. Cytokines such as IL-1,
and neuropeptide content of synovial fluid from patients with
rheumatoid arthritis has revealed a significant correlation between tumor necrosis factor-α (TNF-α) and IL-6 are produced
two neuropeptides, bombesin/gastri
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