genetic management of infectious diseases a heterogeneous epidemio-genetic model illustrated with s. aureus mastitis传染性疾病的遗传管理异构epidemio-genetic模型说明了金黄色葡萄球菌乳腺炎.pdfVIP

Genet. Sel. Evol. 37 (2005) 437–453 437 c INRA, EDP Sciences, 2005 DOI: 10.1051/gse:2005010 Original article Genetic management of infectious diseases: a heterogeneous epidemio-genetic model illustrated with S. aureus mastitis Johann C. D∗ Quantitative Genetics Group, Department of Animal Production, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium (Received 7 October 2004; accepted 27 January 2005) Abstract – Given that individuals are genetically heterogeneous in their degree of resistance to infection, a model is proposed to formulate appropriate choices that will limit the spread of an infectious disease. The model is illustrated with data on S. aureus mastitis and is based on parameters characterizing the spread of the disease (contact rate, probability of infection after contact, and rate of recovery after infection), the demography (replacement and culling rates) and the genetic composition (degree of relationship and heritability of the disease trait) of the animal population. To decrease infection pressure, it is possible to apply non-genetic procedures that increase the culling (e.g., culling of chronically infected cows) and recovery (e.g., antibiotic therapy) rates of infected cows. But the contribution of the paper is to show that genetic man- agement of infectious disease is also theoretically possible as a control measure c