原创力文档histopathological analysis of vesicular and bullous lesions in kaposi sarcoma组织病理学分析卡波西肉瘤的水泡和大疱的病变.pdfVIP
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histopathological analysis of vesicular and bullous lesions in kaposi sarcoma组织病理学分析卡波西肉瘤的水泡和大疱的病变
Kandemir et al. Diagnostic Pathology 2012, 7:101
/content/7/1/101
RESEARCH Open Access
Histopathological analysis of vesicular and bullous
lesions in Kaposi sarcoma
1* 1 1 2 3
Nilüfer Onak Kandemir , Figen Barut , Banu Doğan Gün , Nilgün Solak Tekin , Sevinç Hallaç Keser
and Şükrü Oğuz Özdamar1
Abstract
Background: In this study, the clinical and morphological features of vesiculobullous lesions observed in Kaposi
sarcoma are analyzed, and the features of bullous Kaposi sarcoma cases are emphasized.
Methods: A total of 178 biopsy materials of 75 cases diagnosed as classic-type cutaneous Kaposi sarcoma were
reviewed. Twenty-five cases showing vesiculobullous features were included in the study. Tumor, epidermis, dermis,
and clinical data regarding these cases was evaluated.
Results: Vesicular changes were observed in 21 (12%) out of 178 lesions of the 75 cases, while bullous changes
were present in only 4 (2%). In all cases where vesicular and bullous changes were detected, tumor, epidermis, and
dermis changes were similar. All cases were nodular stage KS lesions, whereas hyperkeratosis and serum exudation
in the epidermis, marked edema in the dermis, and enlarged lymphatic vessels and chronic inflammatory response
were observed.
Conclusions: Our findings suggest that changes in vascular resistance occurring during tumor progression are the
most important factors comprising vesiculobullous morphology.
Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/
vs/1646397188748474
Keywords: Kaposi sarcoma, Bullous Kaposi sarcoma, Histological variants, Lymphangioma-like Kaposi sarcoma
Background
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