influences of dryopteris crassirhizoma extract on the viability, growth and virulence properties of streptococcus mutans粗茎鳞毛蕨提取物的影响生存能力,增长和变形链球菌毒力的性质.pdfVIP

Molecules 2012, 17, 9231-9244; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Influences of Dryopteris crassirhizoma Extract on the Viability, Growth and Virulence Properties of Streptococcus mutans Suk-Ho Ban 1,†, Jeong-Eun Kim 1,†, Santosh Pandit 1 and Jae-Gyu Jeon 1,2,* 1 Department of Preventive Dentistry, School of Dentistry, Institute of Oral Bioscience and BK 21 Program, Chonbuk National University, Jeonju 561-756, Korea 2 Natural Product Research Group in Oral Biology (NatPROB), Jeonju 561-756, Korea † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: dentjjk@jbnu.ac.kr; Tel.: +82-63-270-4036; Fax: +82-63-270-4004. Received: 9 July 2012; in revised form: 27 July 2012 / Accepted: 27 July 2012 / Published: 2 August 2012 Abstract: Dryopteris crassirhizoma is traditionally used as an herbal remedy for various diseases, and has been identified in a previous study as a potential anti-caries agent. In this study, the effect of a methanol extract of D. crassirhizoma on the viability, growth and virulence properties of Streptococcus mutans, a cariogenic dental pathogen, was investigated. In addition, the phytochemical composition of the extract was analyzed. The extract showed bactericidal and bacteriostatic activity against oral bacteria (MIC and MBC of S. mutans: 62.5 and 250 μg/mL, respectively). At two times the MBC, the extract significantly