原创力文档interleukin-10 gene down-expression in circulating mononuclear cells during infusion of drotrecogin-α activated a pilot study在循环单核细胞白细胞介素- 10u201d基因抑制注入drotrecogin-α激活一个试点研究.pdfVIP
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interleukin-10 gene down-expression in circulating mononuclear cells during infusion of drotrecogin-α activated a pilot study在循环单核细胞白细胞介素- 10u201d基因抑制注入drotrecogin-α激活一个试点研究
Lavaux et al. Critical Care 2010, 14:R163
/content/14/5/R163
RESEARCH Open Access
Interleukin-10 gene down-expression in
circulating mononuclear cells during infusion of
drotrecogin-a activated: a pilot study
1 2* 3 1 1 2
Thomas Lavaux , Pascal Bilbault , Anne Launoy , Marie-Pierre Gaub , Pierre Oudet , Francis Schneider
Abstract
Introduction: The purpose of this study was to investigate the gene expression of interferon-gamma (IFN-g),
tumor necrosis factor-alpha (TNF-a) and interleukin-10 (IL-10) in circulating mononuclear cells harvested from septic
shock patients on drotrecogin-a activated (DAA) in order to determine whether this treatment has any effect on
the inflammation phase.
Methods: We conducted a prospective cohort study in two intensive care departments. Blood samples were
collected at inclusion (T1) and 36 hours later (T2) to measure plasma cytokines and the changes in intracellular
TNF-a, IL-10 and IFN-g mRNA expressions using the real-time quantitative polymerase chain reaction (RT-qPCR).
Thirty-two septic shock patients were included: 16 with DAA at 24 μg/kg/h for 96 hours (DAA+) and 16 control
(DAA-) eligible but contraindicated for DAA because of low platelet count.
Results: The basal characteristics were similar in both groups: mortality (50%), plasma cytokine concentrations, and
baseline IFN-g, TNF-a and IL-10 mRNA expressions (DAA+ vs. DAA-). At T2, there was a significant IFN-g gene
down-regulation in DAA+ but not in DAA- patients (-0.34 (-0.62; +1.54) vs. +1.41 (+0.35; +5.87), P = 0.008). In
survivors, DAA administration was associated with a down-expression of both IFN-g (-0.65 (-0.93; 0.48) vs. +0.7
(-0.04; +1.26), P = 0.01) and IL-10 (-0.78 (-0.92; -0.6)
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