原创力文档interleukin-18 a therapeutic target in rheumatoid arthritisinterleukin-18类风湿性关节炎的治疗目标.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
interleukin-18 a therapeutic target in rheumatoid arthritisinterleukin-18类风湿性关节炎的治疗目标
Arthritis Research Therapy Vol 7 No 1 McInnes et al.
Commentary
Interleukin-18: a therapeutic target in rheumatoid arthritis?
Iain B McInnes, Foo Y Liew and J Alastair Gracie
Division of Immunology, Infection and Inflammation, University of Glasgow, UK
Corresponding author: Iain B McInnes, i.b.mcinnes@clinmed.gla.ac.uk
Published: 17 December 2004
Arthritis Res Ther 2005, 7:38-41 (DOI 10.1186/ar1497)
© 2004 BioMed Central Ltd
Abstract
Interleukin 18 (IL-18), a member of the IL-1 superfamily of cytokines has been demonstrated to be an
important mediator of both innate and adaptive immune responses. Several reports have implicated
its role in the pathogenesis of rheumatoid arthritis (RA). Although biologic therapy is firmly
established in the treatment of a number of inflammatory diseases including RA, partial and non-
responder patients constitute residual unmet clinical need. The aim of this article is to briefly review
the biology of, and experimental approaches to IL-18 neutralisation, together with speculation as to
the relative merits of IL-18 as an alternative to existing targets.
Keywords: cytokine, IL-18, inflammation rheumatoid arthritis
Whereas TNFα antagonists provide impressive clinical leukocytes), IL-18 is cleaved by caspase-1 to an active
benefits in rheumatoid arthritis (RA), partial and non- 18 kD ligand, that binds a heterodimeric receptor,
responder patients constitute residual unmet clinical need. consisting of IL-18Rα and IL-18Rβ, that
您可能关注的文档
- hla-c locus alleles may modulate the clinical expression of psoriatic arthritishla-c位点等位基因可以调节银屑病关节炎的临床表现.pdf
- hivaids in vancouver, british columbia a growing epidemic条件在温哥华,不列颠哥伦比亚省日益流行.pdf
- hla class ii dr and dq genotypes and haplotypes associated with rheumatic fever among a clinically homogeneous patient population of latvian childrenhla二类博士和dq基因型和单体型与风湿热在临床上均匀患者人群拉脱维亚的孩子.pdf
- hivbrainseqdb a database of annotated hiv envelope sequences from brain and other anatomical siteshivbrainseqdb数据库的注释hiv信封序列从大脑和其他解剖网站.pdf
- hla-g and hla-e specific mrnas connote opposite prognostic significance in renal cell carcinomahla-g和hla-e特定mrna意味着相反的肾细胞癌的预后意义.pdf
- hog1 bypasses stress-mediated down-regulation of transcription by rna polymerase ii redistribution and chromatin remodelinghog1绕过stress-mediated下调转录的rna聚合酶ii再分配和染色质重塑.pdf
- home and community based care program assessment for people living with hivaids in arba minch, southern ethiopia家庭和社区护理项目评估人生活条件在亚明奇,埃塞俄比亚南部.pdf
- home and office blood pressure control among treated hypertensive patients in japan findings from the japan home versus office blood pressure measurement evaluation (j-home) study家里和办公室治疗高血压患者血压控制在日本发现的日本家庭和办公室血压测量评估(j-home)研究.pdf
- hla-cw04 allele associated with nevirapine-induced rash in hiv-infected thai patientshla-cw04等位基因与nevirapine-induced泰国感染艾滋病毒的患者的皮疹.pdf
- hodgkin's lymphoma presenting with markedly elevated ige a case report霍奇金淋巴瘤有明显升高ige案例报告.pdf
- internal dynamics of dendritic molecules probed by pyrene excimer formation树枝状分子的内部动态探测的芘准分子的形成.pdf
- internal carotid artery dissection following chiropractic treatment in a pregnant woman with systemic lupus erythematosus颈内动脉解剖后按摩治疗系统性红斑狼疮的孕妇.pdf
- interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesisinterleukin-34由人类呈类风湿性关节炎滑膜细胞支持osteoclastogenesis.pdf
- international nurse recruitment and nhs vacancies a cross-sectional analysis国际护士招聘和nhs空缺一个横截面分析.pdf
- international migration and caesarean birth a systematic review and meta-analysis国际移民和剖腹产的系统回顾和荟萃分析.pdf
- interleukin-6 is the strongest predictor of 30-day mortality in patients with cardiogenic shock due to myocardial infarction白细胞介素- 6的最强预测30天死亡率心原性休克患者由于心肌梗塞.pdf
- internalized stigma among patients with schizophrenia in ethiopia a cross-sectional facility-based study内化耻辱中精神分裂症患者在埃塞俄比亚横断面医疗机构的一项研究.pdf
- internal gallbladder drainage prevents development of acute cholecystitis in a pig model a randomized study内部急性胆囊炎胆囊引流阻碍发展的一头猪模型随机研究.pdf
- international genomic evaluation methods for dairy cattle国际奶牛基因评价方法.pdf
- interleukin-17a upregulates receptor activator of nf-κb on osteoclast precursors的nf-κb interleukin-17a移植受体激活破骨细胞前体.pdf
文档评论（0）