原创力文档hog1 bypasses stress-mediated down-regulation of transcription by rna polymerase ii redistribution and chromatin remodelinghog1绕过stress-mediated下调转录的rna聚合酶ii再分配和染色质重塑.pdfVIP
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hog1 bypasses stress-mediated down-regulation of transcription by rna polymerase ii redistribution and chromatin remodelinghog1绕过stress-mediated下调转录的rna聚合酶ii再分配和染色质重塑
Nadal-Ribelles et al. Genome Biology 2012, 13:R106
/2012/13/11/R106
RESEARCH Open Access
Hog1 bypasses stress-mediated down-regulation
of transcription by RNA polymerase II
redistribution and chromatin remodeling
1† 1† 2 3 3,4 2
Mariona Nadal-Ribelles , Núria Conde , Oscar Flores , Juan González-Vallinas , Eduardo Eyras , Modesto Orozco ,
Eulàlia de Nadal1* and Francesc Posas1*
Abstract
Background: Cells are subjected to dramatic changes of gene expression upon environmental changes. Stress
causes a general down-regulation of gene expression together with the induction of a set of stress-responsive
genes. The p38-related stress-activated protein kinase Hog1 is an important regulator of transcription upon
osmostress in yeast.
Results: Genome-wide localization studies of RNA polymerase II (RNA Pol II) and Hog1 showed that stress induced
major changes in RNA Pol II localization, with a shift toward stress-responsive genes relative to housekeeping
genes. RNA Pol II relocalization required Hog1, which was also localized to stress-responsive loci. In addition to
RNA Pol II-bound genes, Hog1 also localized to RNA polymerase III-bound genes, pointing to a wider role for Hog1
in transcriptional control than initially expected. Interestingly, an increasing association of Hog1 with stress-
responsive genes was strongly correlated with chromatin remodeling and increased gene expression. Remarkably,
MNase-Seq analysis showed that although chromatin structure was not significantly altered at a genome-wide level
in response to stress, there was pronounced chromatin remodeling for those genes that displayed Hog1
association.
Conclusion: Hog1 serves to bypass the general down
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