原创力文档hla-g and hla-e specific mrnas connote opposite prognostic significance in renal cell carcinomahla-g和hla-e特定mrna意味着相反的肾细胞癌的预后意义.pdfVIP
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hla-g and hla-e specific mrnas connote opposite prognostic significance in renal cell carcinomahla-g和hla-e特定mrna意味着相反的肾细胞癌的预后意义
Kren et al. Diagnostic Pathology 2012, 7:58
/content/7/1/58
RESEARCH Open Access
HLA-G and HLA-E specific mRNAs connote
opposite prognostic significance in renal
cell carcinoma
1* 2 3 3 4 5 5
Leos Kren , Ivo Valkovsky , Jan Dolezel , Ivo Capak , Dalibor Pacik , Alexandr Poprach , Radek Lakomy ,
5,6 7 8 5,6
Martina Redova , Pavel Fabian , Zdenka Krenova and Ondrej Slaby
Abstract
Background: Renal cell carcinoma (RCC) is characterized by its resistance to radiotherapy and/or chemotherapy. On
the other hand, it is an immunogenic tumor - it is able to stimulate antitumor responses. A prognostic significance
of HLA-G expression by neoplastic cells in RCC is not well characterized; significance HLA-E expression in RCC is not
characterized at all.
Methods: In our study, we evaluated the expression of HLA-G and HLA-E specific mRNA transcripts produced by
neoplastic cells in 38 cases of RCC and in 10 samples of normal kidney parenchyma. The results were statistically
correlated with various clinico-pathological parameters.
Results: We confirmed that HLA-G is downregulated in normal kidney tissue; if it is up-regulated in RCC, then it is
connected to worse prognosis. On the other hand, HLA-E mRNA transcripts were present in both normal kidney
tissue and RCC and their increasing concentrations counterintuitively carried better prognosis, more favorable pT
stage and lower nuclear Fuhrmann’s grade.
Conclusion: Considering the fact that there is known aberrant activation of HLA-G and HLA-E expression by
interferons, identification of HLA-G and HLA-E status could contribute to better selection of RCC patients who co
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