原创力文档intravenous magnesium sulphate for aneurysmal subarachnoid hemorrhage an updated systemic review and meta-analysis静脉注射硫酸镁对动脉瘤性蛛网膜下腔出血一个更新的系统回顾和荟萃分析.pdfVIP
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intravenous magnesium sulphate for aneurysmal subarachnoid hemorrhage an updated systemic review and meta-analysis静脉注射硫酸镁对动脉瘤性蛛网膜下腔出血一个更新的系统回顾和荟萃分析
Wong et al. Critical Care 2011, 15:R52
/content/15/1/R52
RESEARCH Open Access
Intravenous magnesium sulphate for aneurysmal
subarachnoid hemorrhage: an updated systemic
review and meta-analysis
1* 2 1 3 3 1 4
George KC Wong , Ronald Boet , Wai S Poon , Matthew TV Chan , Tony Gin , Stephanie CP Ng , Benny CY Zee
Abstract
Introduction: Previous meta-analyses of magnesium sulphate infusion in the treatment of aneurysmal
subarachnoid hemorrhage (SAH) have become outdated due to recently published clinical trials. Our aim was thus
to perform an up-to-date systemic review and meta-analysis of published data on the use of magnesium sulphate
infusion in aneurysmal SAH patients.
Methods: A systemic review and meta-analysis of the literature was carried out on published randomized
controlled clinical trials that investigated the efficacy of magnesium sulphate infusion in aneurysmal SAH patients.
The results were analyzed with regard to delayed cerebral ischemia (DCI), delayed cerebral infarction, and favorable
neurological outcomes at three and six months. The risks of bias were assessed using the Jadad criteria, with a
Jadad score 3 indicating a lower such risk. Meta-analyses are presented in terms of relative risk (RR) with 95%
confidence intervals (CIs).
Results: Six eligible studies with 875 patients were reviewed. The pooled RR for DCI was 0.87 (95% CI, 0.36 to 2.09;
P = 0.75). That for delayed cerebral infarction was 0.58 (95% CI, 0.35 to 0.97; P = 0.04), although this result did not
persist if only randomized clinical trials with a lower risk of bias were included (RR 0.61, 95% CI, 0.31 to 1.22; P =
0.17). The pooled RR for a favorable outcome at three months was 1.14 (95% CI,
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