isostreptazolin and sannaphenol, two new metabolites from streptomyces sannanensisisostreptazolin sannaphenol,两个新的代谢物从链霉菌属sannanensis.pdfVIP

Molecules 2012, 17, 836-842; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Isostreptazolin and Sannaphenol, Two New Metabolites from Streptomyces sannanensis Dan Zheng 1,†, Li Han 1,†, Yiqing Li 2,*, Jun Li 2, He Rong 2, Qiao Leng 1, Yi Jiang 2, Lixing Zhao 2 and Xueshi Huang 1,* 1 Ministry of Health Key Laboratory of Congenital Malformation, Laboratory of Metabolic Disease Research and Drug Development, China Medical University, Shenyang 110001, China 2 Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, Yunnan University, Kunming 650091, China † These authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mails: xshuang@ (X.H.); yiqingli@ (Y.L.). Received: 3 November 2011; in revised form: 12 January 2012 / Accepted: 13 January 2012 / Published: 16 January 2012 Abstract: Two new compounds, isostreptazolin (1) and sannaphenol (2), were isolated from the culture broth of Streptomyces sannanensis and their structures elucidated on the basis of 1D and 2D NMR as well as MS, IR and UV spectroscopic data analysis. The cytotoxic activity of 1 and 2 were evaluated. Both compounds were inactive against H460 and HeLa cell lines at 100 M. Keywords: isostreptazolin; sannaphenol; Streptomyces sannanensis 1. Introduction In the course of screening for new bioactive compounds from microbial sources, two new constituents, isostreptazolin (1) an