isolation and immunomodulatory effect of homoisoflavones and flavones from agave sisalana perrine ex engelm.隔离和免疫调节效应homoisoflavones和黄酮的龙舌兰珀赖因sisalana engelm交货。.pdfVIP

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isolation and immunomodulatory effect of homoisoflavones and flavones from agave sisalana perrine ex engelm.隔离和免疫调节效应homoisoflavones和黄酮的龙舌兰珀赖因sisalana engelm交货。.pdf

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isolation and immunomodulatory effect of homoisoflavones and flavones from agave sisalana perrine ex engelm.隔离和免疫调节效应homoisoflavones和黄酮的龙舌兰珀赖因sisalana engelm交货。

Molecules 2009, 14, 1789-1795; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Isolation and Immunomodulatory Effect of Homoisoflavones and Flavones from Agave sisalana Perrine ex Engelm. Pi Yu Chen 1, Yuh Chi Kuo 2, Chin Hui Chen 1, Yueh Hsiung Kuo 3,4,* and Ching Kuo Lee 1,* 1 Graduate Institute of Pharmacy, Taipei Medical University, 250 Wu Xin Street, Taipei 11031, Taiwan; E-mail: e023089103@.tw (P-Y.C), chinhui@.tw (C-H.C.) 2 Institute of Life Science, Fu-Jen University; 510 Chung Cheng Rd, Hsinchuang, Taipei 24205, Taiwan; E-mail: 021553@.tw (Y-H.K) 3 Tsutzki Institute for Traditional Medicine, China Medical University, 91 Hsueh Shih Road, Taichung 40402, Taiwan 4 Agricultural Biotechnology Research Center, Academia Sinica, 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan * Author to whom correspondence should be addressed; E-mail: cklee@.tw (C-K.L) or yhkuo@.tw (Y-H.K.); Tel.: +886 2ext. 6150; Fax: +886 2 Received: 2 April 2009; in revised form: 29 April 2009 / Accepted: 30 April 2009 / Published: 12 May 2009 Abstract: Three known flavones and seven known homoisoflavonoids were isolated from the methanolic extract of the leaves of Agave sisalana Perrine ex Engelm. Their structures were elucidated on the basis of spectroscopic analysis. The isolated compounds were also evaluated for immunopharmacological activity. PBMC were used as target cells, and cell proliferation was determined by 3H-thymidine uptake. (±)-3,9-Dihydroeucomin (4), dihydrobonducel