human metabolic network reconstruction, simulation, and applications in systems biology人类代谢网络重构、模拟和应用程序在系统生物学.pdfVIP

Metabolites 2012, 2, 242-253; doi:10.3390/metabo2010242 OPEN ACCESS metabolites ISSN 2218-1989 /journal/metabolites/ Review Human Metabolic Network: Reconstruction, Simulation, and Applications in Systems Biology Ming Wu 1,* and Christina Chan 1,2,3,* 1 Department of Computer Science and Engineering, Michigan State University, East Lansing, MI 48824, USA 2 Department of Chemical Engineering and Material Scince, Michigan State University, East Lansing, MI 48824, USA 3 Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824,USA * Authors to whom correspondence should be addressed; E-Mails: wuming1@ (M.W.); krischan@ (C.C.); Tel.: +1-517-432-4530 (C.C.); Fax: +1-517-432-1105 (C.C.). Received: 30 January 2012; in revised form: 18 February 2012 / Accepted: 27 February 2012 / Published: 2 March 2012 Abstract: Metabolism is crucial to cell growth and proliferation. Deficiency or alterations in metabolic functions are known to be involved in many human diseases. Therefore, understanding the human metabolic system is important for the study and treatment of complex diseases. Current reconstructions of the global human metabolic network provide a computational platform to integrate genome-scale information on metabolism. The platform enables a systematic study of the regulation and is applicable to a wide variety of cases, wherein one could rely on in silico perturbations to predict novel targets, interpret systemic effects, and