原创力文档hyperhomocysteinemia is independently associated with albuminuria in the population-based colaus study半胱氨酸在以人群为基础的独立与蛋白尿colaus研究.pdfVIP
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hyperhomocysteinemia is independently associated with albuminuria in the population-based colaus study半胱氨酸在以人群为基础的独立与蛋白尿colaus研究
Marti et al. BMC Public Health 2011, 11:733
/1471-2458/11/733
RESEARCH ARTICLE Open Access
Hyperhomocysteinemia is independently
associated with albuminuria in the population-
based CoLaus study
1 2 1,3 4 2
Franziska Marti , Peter Vollenweider , Pedro-Manuel Marques-Vidal , Vincent Mooser , Gérard Waeber ,
Fred Paccaud1 and Murielle Bochud1*
Abstract
Background: Increased serum levels of homocysteine and uric acid have each been associated with cardiovascular
risk. We analyzed whether homocysteine and uric acid were associated with glomerular filtration rate (GFR) and
albuminuria independently of each other. We also investigated the association of MTHFR polymorphisms related to
homocysteine with albuminuria to get further insight into causality.
Methods: This was a cross-sectional population-based study in Caucasians (n = 5913). Hyperhomocysteinemia was
defined as total serum homocysteine ≥ 15 μmol/L. Albuminuria was defined as urinary albumin-to-creatinine ratio
30 mg/g.
Results: Uric acid was associated positively with homocysteine (r = 0.246 in men and r = 0.287 in women, P
0.001). The prevalence of albuminuria increased across increasing homocysteine categories (from 6.4% to 17.3% in
subjects with normal GFR and from 3.5% to 14.5% in those with reduced GFR, P for trend 0.005).
Hyperhomocysteinemia (OR = 2.22, 95% confidence interval: 1.60-3.08, P 0.001) and elevated serum uric acid (OR
= 1.27, 1.08-1.50, per 100 μmol/L, P = 0.004) were significantly associated with albuminuria, independently of
hypertension and type 2 diabetes. The 2-fold higher risk of albuminuria associated with hyperhomocysteinemia
was similar to the risk associated with hypertension or diabetes. MTHF
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