mapping similarities in mtor pathway perturbations in mouse lupus nephritis models and human lupus nephritis扰动映射相似之处mtor途径在小鼠狼疮肾炎模型和人类的狼疮肾炎.pdfVIP
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mapping similarities in mtor pathway perturbations in mouse lupus nephritis models and human lupus nephritis扰动映射相似之处mtor途径在小鼠狼疮肾炎模型和人类的狼疮肾炎
Available online /content/10/6/R127
Vol 10 No 6 Open Access
Research article
Mapping similarities in mTOR pathway perturbations in mouse
lupus nephritis models and human lupus nephritis
1 1 2 3 4
Padmalatha S Reddy *, Holly M Legault *, Joseph P Sypek , Mark J Collins , Elizabeth Goad ,
2 1 1 5 1
Samuel J Goldman , Wei Liu , Stuart Murray , Andrew J Dorner and Margot OToole
1Biological Technologies, Wyeth Research, Cambridge, 35 CambridgePark Drive, Massachusetts 02140, USA
2Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA
3Polysaccharides Quality, Wyeth Pharmaceutical, 1 Burtt Rd, Andover, MA 01810, USA
4Stryker Biotech, 35 South St, Hopkinton, MA 01748, USA
5ajDorner Consulting, 20 Baskin Road, Lexington, MA 02421, USA
* Contributed equally
Corresponding author: Margot OToole, motoole@
Received: 20 Jun 2008 Revisions requested: 15 Jul 2008 Revisions received: 22 Sep 2008 Accepted: 3 Nov 2008 Published: 3 Nov 2008
Arthritis Research Therapy 2008, 10:R127 (doi:10.1186/ar2541)
This article is online at: /content/10/6/R127
© 2008 Reddy et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction Treatment with sirolimus, a mammalian target of explored using information from sever
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