原创力文档molecular characteristics and chromatin texture features in acute promyelocytic leukemia急性早幼粒细胞白血病分子特征和染色质结构特性.pdfVIP
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molecular characteristics and chromatin texture features in acute promyelocytic leukemia急性早幼粒细胞白血病分子特征和染色质结构特性
Mello et al. Diagnostic Pathology 2012, 7:75
/content/7/1/75
RESEARCH Open Access
Molecular characteristics and chromatin texture
features in acute promyelocytic leukemia
1 2 2 3
Mariana R. B. De Mello , Dulcineia M. Albuquerque , Fernanda Gonçalves Pereira-Cunha , Krizzia B Albanez ,
2 1 3 2*
Katia B. B. Pagnano , Fernando F. Costa , Konradin Metze and Irene Lorand-Metze
Abstract
Background: Acute promyelocytic leukemia is a cytogenetically well defined entity. Nevertheless, some features
observed at diagnosis are related to a worse outcome of the patients.
Methods: In a prospective study, we analyzed peripheral (PB) leukocyte count, immunophenotype, methylation
status of CDKN2B, CDKN2A and TP73; FLT3 and NPM1 mutations besides nuclear chromatin texture characteristics
of the leukemic cells. We also examined the relation of these features with patient’s outcome.
Results: Among 19 cases, 4 had a microgranular morphology, 7 presented PB leukocytes 10x109/l, 2 had FLT3-ITD
and 3 had FLT3-TKD (all three presenting a methylated CDKN2B). NPM1 mutation was not observed. PB leukocyte
count showed an inverse relation with standard deviation of gray levels, contrast, cluster prominence, and
chromatin fractal dimension (FD). Cases with FLT3-ITD presented a microgranular morphology, PB leukocytosis and
expression of HLA-DR, CD34 and CD11b. Concerning nuclear chromatin texture variables, these cases had a lower
entropy, contrast, cluster prominence and FD, but higher local homogeneity, and R245, in keeping with more
homogeneously distributed chromatin. In the univariate Cox analysis, a
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