原创力文档mutations in the 23s rrna gene are associated with clarithromycin resistance in helicobacter pylori isolates in brazil23 s rrna基因的突变与克拉霉素抵抗幽门螺旋杆菌分离株在巴西.pdfVIP
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mutations in the 23s rrna gene are associated with clarithromycin resistance in helicobacter pylori isolates in brazil23 s rrna基因的突变与克拉霉素抵抗幽门螺旋杆菌分离株在巴西
Annals of Clinical Microbiology and
Antimicrobials BioMed Central
Research Open Access
Mutations in the 23S rRNA gene are associated with clarithromycin
resistance in Helicobacter pylori isolates in Brazil
Marcelo L Ribeiro, Lea Vitiello, Maira CB Miranda, Yune HB Benvengo,
Anita PO Godoy, Sergio Mendonca and José Pedrazzoli Jr*
Address: Clinical Pharmacology and Gastroenterology Unit, São Francisco University Medical School, Bragança Paulista, SP, Brazil
Email: Marcelo L Ribeiro - marceloribeiro@.br; Lea Vitiello - lea@.br;
Maira CB Miranda - maira@.br; Yune HB Benvengo - yune@.br;
Anita PO Godoy - anita@.br; Sergio Mendonca - sergiomendonca@.br;
José Pedrazzoli* - pedrazzoli@.br
* Corresponding author
Published: 21 November 2003 Received: 06 October 2003
Accepted: 21 November 2003
Annals of Clinical Microbiology and Antimicrobials 2003, 2:11
This article is available from: /content/2/1/11
© 2003 Ribeiro et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all
media for any purpose, provided this notice is preserved along with the articles original URL.
Abstract
Background: Resistance of Helicobacter pylori to clarithromycin has been associated with A2142G
and A2143G point mutations in the 23S rRNA gene. Thus, the purpose of the present study was
to determine the prevalence of each mutation in 52 clarithromycin-resistant H. pylori strains and to
characterize the influence each type of mutation on the MIC.
Methods: The
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