n？-{[2-(piperidin-1-yl)quinolin-3-yl]methylene}pyridine-4-carbohydraziden - {[2 -(piperidin-1-yl)quinolin-3-yl]亚甲基} pyridine-4-carbohydrazide.pdfVIP

Molbank 2012, M748; doi: 10.3390/M748 OPEN ACCESS molbank ISSN 1422-8599 /journal/molbank Short Note Nꞌ-{[2-(Piperidin-1-yl)quinolin-3-yl]methylene}pyridine-4- carbohydrazide Obaid Afzal, Sandhya Bawa *, Suresh Kumar and Rajiv K. Tonk Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi, 110062, India * Author to whom correspondence should be addressed; E-Mail: sbawa@jamiahamdard.ac.in. Received: 6 January 2012 / Accepted: 10 January 2012 / Published: 18 January 2012 Abstract: Nꞌ- {[2-(piperidin-1-yl)quinolin-3-yl]methylene}pyridine-4-carbohydrazide 2 has been synthesized through condensation of 2-(piperidin-1-yl)quinoline-3-carbaldehyde 1 with isonicotinic acid hydrazide (INH) in absolute ethanol. The structure of the title compound 2 was established on the basis of IR, 1H-NMR, 13C-NMR and mass spectral data. Keywords: 2-piperidinylquinoline; isonicotinic acid hydrazide Literature review revealed that the quinoline moiety exists in a variety of biologically active compounds. They exhibit antimicrobial, anticancer, anti-inflammatory, anti-HIV, antidepressant, antidiabetic, anti-epileptic etc. activities [1–7]. The target compound of the present communication was designed based on the fact that Quipazine [2-(1-piperzinyl)quinoline] produces a weak inhibition of monoamine oxidase in both in-vitro and in-vivo studies [8]. The biological importance of Quipazine as antidepressant has