mouse maps of gene expression in the brain老鼠大脑中的基因表达的地图.pdfVIP

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mouse maps of gene expression in the brain老鼠大脑中的基因表达的地图.pdf

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mouse maps of gene expression in the brain老鼠大脑中的基因表达的地图

Minireview Mouse maps of gene expression in the brain Susan E Koester* and Thomas R Insel† Addresses: *Division of Neuroscience and Basic Behavioral Science, National Institute of Mental Health, Executive Blvd, Bethesda, MD 20892-9645, USA. †National Institute of Mental Health, Executive Blvd, Bethesda, MD 20892-9645, USA. Correspondence: Thomas R Insel. Email: tinsel@ Published: 18 May 2007 Genome Biology 2007, 8:212 (doi:10.1186/gb-2007-8-5-212) The electronic version of this article is the complete one and can be found online at /2007/8/5/212 © 2007 BioMed Central Ltd Abstract The completion of the Allen Brain Atlas generated a great deal of press interest and enthusiasm from the research community. What does it do, and what other complementary resources increase its functionality? Since the 19th century, neuroscientists have struggled to methods developed by collaborators Gregor Eichele and Axel categorize the types of cells in the brain using anatomical or Visel [5] on rigorously controlled coronal sections through physiological markers as an indication of cell function [1]. the entire postnatal day (P) 56 (adult) male mouse brain. Subdivisions of the brain are defined by clusters of neurons Colorimetric in situ hybridization data for 21,000 genes are related by cellular architecture, connectional specificity or now posted online with open access [4]. The data are physiological properties. In the past 20 years, neuroscientists searchable by gene names or symbols, as well as by large have added molecular biology to their arsenal of tools for anatomical regions (for example, cortex, midbrain, categorizing brain