原创力文档morphological changes in diabetic kidney are associated with increased o-glcnacylation of cytoskeletal proteins including α-actinin 4在糖尿病肾脏形态学改变与增加细胞骨架蛋白的o-glcnacylation包括α-actinin 4.pdfVIP
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morphological changes in diabetic kidney are associated with increased o-glcnacylation of cytoskeletal proteins including α-actinin 4在糖尿病肾脏形态学改变与增加细胞骨架蛋白的o-glcnacylation包括α-actinin 4
Akimoto et al. Clinical Proteomics 2011, 8:15
/content/8/1/15 CLINICAL
PROTEOMICS
RESEARCH Open Access
Morphological changes in diabetic kidney are
associated with increased O-GlcNAcylation of
cytoskeletal proteins including a-actinin 4
1* 2 2 3 3,4,5 3,4
Yoshihiro Akimoto , Yuri Miura , Tosifusa Toda , Margreet A Wolfert , Lance Wells , Geert-Jan Boons ,
Gerald W Hart6, Tamao Endo2 and Hayato Kawakami1
* Correspondence: yakimoto@ks. Abstract
kyorin-u.ac.jp
1Department of Anatomy, Kyorin Purpose: The objective of the present study is to identify proteins that change in
University School of Medicine,
Mitaka, Tokyo 181-8611, Japan the extent of the modification with O-linked N-acetylglucosamine (O-GlcNAcylation)
Full list of author information is in the kidney from diabetic model Goto-Kakizaki (GK) rats, and to discuss the relation
available at the end of the article
between O-GlcNAcylation and the pathological condition in diabetes.
Methods: O-GlcNAcylated proteins were identified by two-dimensional gel
electrophoresis, immunoblotting and peptide mass fingerprinting. The level of
O-GlcNAcylation of these proteins was examined by immunoprecipitation,
immunoblotting and in situ Proximity Ligation Assay (PLA).
Results: O-GlcNAcylated proteins that changed significantly in
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