mouse models targeting selenocysteine trna expression for elucidating the role of selenoproteins in health and development小鼠模型针对硒代半胱氨酸trna表达式阐明硒蛋白的作用在健康和发展.pdfVIP

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mouse models targeting selenocysteine trna expression for elucidating the role of selenoproteins in health and development小鼠模型针对硒代半胱氨酸trna表达式阐明硒蛋白的作用在健康和发展.pdf

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mouse models targeting selenocysteine trna expression for elucidating the role of selenoproteins in health and development小鼠模型针对硒代半胱氨酸trna表达式阐明硒蛋白的作用在健康和发展

Molecules 2009, 14, 3509-3527; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Mouse Models Targeting Selenocysteine tRNA Expression for Elucidating the Role of Selenoproteins in Health and Development Bradley A. Carlson 1,*, Min-Hyuk Yoo 1, Petra A. Tsuji 1,2,3, Vadim N. Gladyshev 4 1 and Dolph L. Hatfield 1 Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; E-mails: yoom@ (M-H.Y.); tsujipa@ (P.A.T.); hatfield@ (D.L.H.) 2 Cancer Prevention Fellowship Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA 3 Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA 4 Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, NE 68588, USA; E-mail: vgladysh@ (V.N.G.) * Author to whom correspondence should be addressed; E-mail: carlsonb@. Received: 17 August 2009; in revised form: 3 September 2009 / Accepted: 7 September 2009 / Published: 10 September 2009 Abstract: Selenium (Se) deficiency has been known for many years to be associated with disease, impaired growth and a variety of other metabolic disorders in mammals. Only recently has the major role that Se-containing proteins, designated selenoproteins, play in many aspects of health and development begun to emerge. Se is inc