mrna a complex(ed) life信使rna复杂(ed)的生活.pdfVIP

Müller et al. Genome Biology 2010, 11:304 /2010/11/5/304 M E E T I N G R E P O R T mRNA: a complex(ed) life Michaela Müller, Karla M Neugebauer* and Christian Eckmann through the poly(A) tail are now coming to light. Abstract Numerous microRNAs (miRNAs) repress translation in A report of the EMBL conference ‘The Complex Life of the context of Argonaute-containing RNA-silencing mRNA: From Synthesis to Decay’, Heidelberg, Germany, complexes. e conserved protein GW182 interacts with 18-21 March 2010. these RNA-silencing complexes and can trigger trans- lational repression upon tethering to the mRNA. A mechanistic model of how GW182 elicits this response An EMBL conference held recently in Heidelberg took on was proposed by Nahum Sonenberg (McGill University, the daunting task of examining the life of mRNAs from Montreal, Canada). He and colleagues have found that start to finish. e assumption of the ‘central dogma’ is the silencing domain in the human GW182 ortholog that mRNA production leads to protein expression. Yet TNRC6C interacts with poly(A)-binding protein (PABP), cellular mRNA levels reflect a balance between the rates revealing an unexpected role for cytoplasmic PABP as a of gene transcription and mRNA degradation and negative regulator of RNA translation. is mo