mucins differently expressed in various ampullary adenocarcinomas黏蛋白的表达在不同的壶腹腺癌.pdfVIP

Wang et al. Diagnostic Pathology 2011, 6:102 /content/6/1/102 RESEARCH Open Access Mucins Differently Expressed in Various Ampullary Adenocarcinomas * Tao Wang, Ye M Liang , Peng Hu and Yu F Cheng Abstract Background: We investigated the occurrence and clinical significance of mucin expression in ampullary adenocarcinoma. Methods: We retrospectively analyzed clinical, pathological, and survival data from 74 ampullary adenocarcinoma patients who received radical operation from January 2004 to November 2006. Results: The tumors were located in the lower end of the common bile duct (46%), papillary duodenum (42%), and ampullary duodenum (12%), and expressed MUC1 (72%), MUC2 (20%), MUC5AC (43%), and MUC6 (27%). Expression of MUC1 was associated with tumor differentiation (OR: 4.71, 95% CI: 1.26, 17.66, P = 0.021). Expression of MUC5AC was associated with age (OR: 1.07, 95% CI: 1.11, 1.14, P = 0.026) and less vessel invasion(OR: 0.14, 95% CI: 0.03, 0.72, P = 0.019). The survival rates were not significantly different when patients had or had no expression of MUC1, MUC2, MUC5AC, or MUC6 in tumor. Patients with tumors positive for MUC5AC in the papillary duodenum had worse survival than those with tumors negative for MUC5AC (P = 0.044). Conclusions: Expression of MUC1 was high (72%) in ampullary adenocarcinoma, while expressions of MUC2, MUC5AC, and MUC6 were lower. Mucins are useful markers to diagnose and identify ampullary adenocarcinoma, particularly in determining the degree of malignancy of ampullary adenocarcinoma. Keywords: mucin, ampulla of Vater, common bile duct, neoplasm staging Background glycosylation structure. The histological differentiation is Ampullary adenocarcinoma, which occurs in the area of