mu opioid receptor availability in people with psychiatric disorders who died by suicide a case control studyμ阿片受体可用性精神障碍患者死于自杀病例对照研究.pdfVIP

Scarr et al. BMC Psychiatry 2012, 12:126 /1471-244X/12/126 RESEARCH ARTICLE Open Access Mu opioid receptor availability in people with psychiatric disorders who died by suicide: a case control study 1,2* 1,2 1 1,2 1,2 Elizabeth Scarr , Tammie Terese Money , Geoffrey Pavey , Jaclyn Neo and Brian Dean Abstract Background: Mu opioid receptors have previously been shown to be altered in people with affective disorders who died as a result of suicide. We wished to determine whether these changes were more widespread and independent of psychiatric diagnoses. Methods: Mu receptor levels were determined using [3 H]DAMGO binding in BA24 from 51 control subjects; 38 people with schizophrenia (12 suicides); 20 people with major depressive disorder (15 suicides); 13 people with bipolar disorder (5 suicides) and 9 people who had no history of psychiatric disorders but who died as a result of suicide. Mu receptor levels were further determined in BA9 and caudate-putamen from 38 people with schizophrenia and 20 control subjects using [3 H]DAMGO binding and, in all three regions, using Western blots. Data was analysed using one-way ANOVAs with Bonferroni’s Multiple Comparison Test or, where data either didn’t approximate to a binomial distribution or the sample size was too small to determine distribution, a Kruskal-Wallis test with Dunn’s Multiple Comparison Test. Results: [3 H]DAMGO binding density was lower in people who had died as a result of suicide (p0.01). People with schizophrenia who had died as a result of suicide had lower binding than control subjects (p0.001), whilst people with bipolar disorder (non- suicide) had higher levels of binding (p0.05). [3 H]DAMGO binding densities, but not mu