mucosal administration of α-fodrin inhibits experimental sj？grens syndrome autoimmunity粘膜管理α-fodrin抑制实验sj gren综合症自身免疫.pdfVIP

Available online /content/10/2/R44 Vol 10 No 2 Open Access Research article Mucosal administration of α-fodrin inhibits experimental Sjögrens syndrome autoimmunity Jing He, Jinxia Zhao and Zhanguo Li Department of Rheumatology Immunology, Peoples Hospital, Peking University Medical School, 11 Xizhimen South Street, Beijing 100044, China Corresponding author: Zhanguo Li, zgli98@ Received: 9 Dec 2007 Revisions requested: 7 Feb 2008 Revisions received: 26 Mar 2008 Accepted: 18 Apr 2008 Published: 18 Apr 2008 Arthritis Research Therapy 2008, 10:R44 (doi:10.1186/ar2403) This article is online at: /content/10/2/R44 © 2008 He et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction α-Fodrin is an autoantigen in Sjögrens syndrome. titers of anti-α-fodrin and anti-M3RP antibodies were lower in We hypothesized that mucosal administration of α-fodrin might immunized mice (P 0.05), but there was no significant prevent the disease. difference between the low-dose or high-dose immunization groups. Five out of eight mice in the GST group, five of eight Methods Four-week-old NOD mice were immunized (intranasal) mice in the PBS group, two of eight mice in the α-fodrin 1 μg/ with a 1 μg or 10 μg dose of α-fodrin every other day. PBS 10 dose group, and three ou