mucocele-like lesions of the breast a long-term follow-up studymucocele-like病变乳房的长期随访研究.pdfVIP

Ohi et al. Diagnostic Pathology 2011, 6:29 /content/6/1/29 SHORT REPORT Open Access Mucocele-like lesions of the breast: a long-term follow-up study 1 2* 1 1 1 1 1 Yasuyo Ohi , Yoshihisa Umekita , Yoshiaki Rai , Yasuaki Sagara , Shinichi Baba , Shugo Tamada , Yoshiaki Sagara , 1 2 2 1 2 Taeko Kukita , Takako Yoshioka , Kazuhito Hatanaka , Yoshiatsu Sagara and Akihide Tanimoto Abstract Background: Mucocele-like lesions (MLL) of the breast were originally described as benign lesions composed of multiple cysts lined by uniform flat to cuboidal epithelium with extravasated mucin, but subsequent reports described the coexistence of columnar cell lesions (CCL), atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS). Several reports have investigated whether core biopsy can diagnose MLL reliably; however, there is only one report with a long-term follow-up after excision of MLL. We report here 15 surgically excised MLL with a long- term follow-up. Findings: Fifteen lesions diagnosed as MLL from 13 patients who had undergone excisional biopsy between January 2001 and December 2006 were retrieved and followed-up for 24-99 months (median 63.8). Two lesions were accompanied with CCL, 5 with ADH and 3 with low grade DCIS. Four lesions (2 ADH, 2 DCIS) were additionally resected and their histology revealed 2 ADH, one DCIS and one MLL with CCL. Of 4 lesions (3 ADH, one DCIS) without additional resection, one lesion (ADH) relapsed accompanied with DCIS at 37 months after excision. Conclusions: MLL were frequently accompanied with CCL, ADH or low grade