mucoadhesive gels designed for the controlled release of chlorhexidine in the oral cavitymucoadhesive凝胶用于控制释放洗必泰的口腔.pdfVIP

Pharmaceutics 2011, 3, 665-679; doi:10.3390/pharmaceutics3040665 OPEN ACCESS pharmaceutics ISSN 1999-4923 /journal/pharmaceutics Article Mucoadhesive Gels Designed for the Controlled Release of Chlorhexidine in the Oral Cavity Adamo Fini 1,*, Valentina Bergamante 1 and Gian Carlo Ceschel 2 1 Department SMETEC, University of Bologna, Bologna, 40127, Italy; E-Mail: valentina.bergamante@unibo.it 2 Monteresearch, Bollate, Milano, 20021, Italy; E-Mail: giancarlo.ceschel@monteresearch.it * Author to whom correspondence should be addressed; E-Mail: adamo.fini@unibo.it; Tel.: +39-051-2095655; Fax: +39-051-2095652. Received: 21 July 2011; in revised form: 9 September 2011 / Accepted: 26 September 2011 / Published: 27 September 2011 Abstract: This study describes the in vitro/ex vivo buccal release of chlorhexidine (CHX) from nine mucoadhesive aqueous gels, as well as their physicochemical and mucoadhesive properties: CHX was present at a constant 1% w/v concentration in the chemical form of digluconate salt. The mucoadhesive/gel forming materials were carboxymethyl- (CMC), hydroxypropylmethyl- (HPMC) and hydroxypropyl- (HPC) cellulose, alone (3% w/w) or in binary mixtures (5% w/w); gels were tested for their mucoadhesion using the mucin method at 1, 2 and 3% w/w concentrations. CHX release from different formulations was assessed using a USP method and newly developed apparatus, combining release/permeation process in which porcine mucosa was placed in a Franz cel