motifs and cis-regulatory modules mediating the expression of genes co-expressed in presynaptic neurons图案和基因工程模块调节基因的表达发生在突触前神经元.pdfVIP

Volume 10, Issue 7, Article R72et al.Liu2009 Open Access Research Motifs and cis-regulatory modules mediating the expression of genes co-expressed in presynaptic neurons Rui Liu, Sridhar Hannenhalli and Maja Bucan Address: Department of Genetics and Penn Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA 19104, USA. Correspondence: Sridhar Hannenhalli. Email: sridharh@. Maja Bucan. Email: bucan@ Published: 1 July 2009 Received: 8 May 2009 Revised: 11 June 2009 Genome Biology 2009, 10:R72 (doi:10.1186/gb-2009-10-7-r72) Accepted: 1 July 2009 The electronic version of this article is the complete one and can be found online at /2009/10/7/R72 © 2009 Liu et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. controlling neuronal-specific expression in presynaptic neurons./pPresynaptic neuron regulatory networkpAn integrative strategy of comparative genomics, experimental and computational approaches reveals aspects of a regulatory network Abstract Background: Hundreds of proteins modulate neurotransmitter release and synaptic plasticity during neuronal development and in response to synaptic activity. The expression of genes in the pre- and post-synaptic neurons is under stringent spatio-temporal control, but the mechanism underlying the neuronal expression of these genes remains largely unknown. Resul