原创力文档n-cadherin is differentially expressed in histological subtypes of papillary renal cell carcinoman-cadherin差异表达在乳头状肾细胞癌的组织学亚型.pdfVIP
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n-cadherin is differentially expressed in histological subtypes of papillary renal cell carcinoman-cadherin差异表达在乳头状肾细胞癌的组织学亚型
Behnes et al. Diagnostic Pathology 2012, 7:95
/content/7/1/95
RESEARCH Open Access
N-cadherin is differentially expressed in
histological subtypes of papillary renal
cell carcinoma
1* 1 2 1 1
Carl Ludwig Behnes , Bernhard Hemmerlein , Arne Strauss , Heinz-Joachim Radzun and Felix Bremmer
Abstract
Background: Papillary renal cell carcinoma (RCC) represents a rare tumor, which is divided, based on histological
criteria, into two subtypes. In contrast to type I papillary RCC type II papillary RCC shows a worse prognosis. So far,
reliable immunohistochemical markers for the distinction of these subtypes are not available.
Methods: In the present study the expression of N(neural)-, E(epithelial)-, P(placental)-, und KSP(kidney specific)-
cadherin was examined in 22 papillary RCC of histological type I and 18 papillary RCC of histological type II
(n = 40).
Results: All papillary RCC type II displayed a membranous expression for N-cadherin, whereas type I did not show
any membranous positivity for N-cadherin. E-cadherin exhibited a stronger, but not significant, membranous as well
as cytoplasmic expression in type II than in type I papillary RCC. A diagnostic relevant expression of P- and
KSP-cadherin could not be demonstrated in both tumor entities.
Conclusion: Thus N-cadherin represents the first immunhistochemical marker for a clear cut differentiation
between papillary RCC type I and type II and could be a target for therapy and diagnostic in the future.
Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/
vs/2011556982761733
Keywords: N-cadherin, Histological subtypes, Papillary renal cell car
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