原创力文档need for insulin to control gestational diabetes is reflected in the ambulatory arterial stiffness index需要控制妊娠糖尿病的胰岛素是反映在走动的动脉硬化指数.pdfVIP
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need for insulin to control gestational diabetes is reflected in the ambulatory arterial stiffness index需要控制妊娠糖尿病的胰岛素是反映在走动的动脉硬化指数
Kärkkäinen et al. BMC Pregnancy and Childbirth 2013, 13:9
/1471-2393/13/9
RESEARCH ARTICLE Open Access
Need for insulin to control gestational diabetes is
reflected in the ambulatory arterial stiffness index
1* 3 1 1 2 3
Henna Kärkkäinen , Tomi Laitinen , Nonna Heiskanen , Heli Saarelainen , Pirjo Valtonen , Tiina Lyyra-Laitinen ,
Esko Vanninen3 and Seppo Heinonen1
Abstract
Background: The aim was to evaluate the metabolic profile in conjunction with vascular function using the
ambulatory arterial stiffness index (AASI) in women with uncomplicated pregnancies and in women with
gestational diabetes mellitus (GDM).
Methods: Plasma glucose, lipids, HOMA –IR (homeostasis model assessment of insulin resistance) and AASI, as
obtained from 24-hour ambulatory blood pressure monitoring in third trimester pregnancy and at three months
postpartum, were measured in three groups of women: controls (N = 32), women with GDM on diet (N = 42) and
women with GDM requiring insulin treatment (N = 10).
Results: Women with GDM had poorer glycemic control and higher HOMA-IR during and after pregnancy and
their total and LDL (low density lipoprotein) cholesterol levels were significantly higher after pregnancy than in the
controls. After delivery, there was an improvement in AASI from 0.26 ± 0.10 to 0.17 ± 0.09 (P = 0.002) in women
with GDM on diet, but not in women with GDM receiving insulin whose AASI tended to worsen after delivery from
0.30 ± 0.23 to 0.33 ± 0.09 (NS), then being significantly higher than in the other groups (P = 0.001-0.047).
Conclusions: Women with GDM had more unfavorable lipid profile and higher blood glucose values at three
months after delivery, the metabolic profile being wo
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