negative association of the chemokine receptor ccr5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis负协会的趋化因子受体ccr5 d32多态性与系统性炎症反应,包含症状在风湿性关节炎和关节侵蚀.pdfVIP

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negative association of the chemokine receptor ccr5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis负协会的趋化因子受体ccr5 d32多态性与系统性炎症反应,包含症状在风湿性关节炎和关节侵蚀.pdf

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negative association of the chemokine receptor ccr5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis负协会的趋化因子受体ccr5 d32多态性与系统性炎症反应,包含症状在风湿性关节炎和关节侵蚀

Available online /content/11/3/R91 Vol 11 No 3 Open Access Research article Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis 1 1 1 2 3 Manuela Rossol , Matthias Pierer , Sybille Arnold , Gernot Keyßer , Harald Burkhardt , Christoph Baerwald1 and Ulf Wagner1 1Division of Rheumatology, Department of Internal Medicine II, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany 2Department of Internal Medicine I, University of Halle/Saale, Ernst-Grube-Straße 40, 06120 Halle/Saale, Germany 3Division of Rheumatology, Department of Internal Medicine II, Johann Wolfgang Goethe University Frankfurt am Main, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany Corresponding author: Manuela Rossol, manuela.rossol@medizin.uni-leipzig.de Received: 5 Dec 2008 Revisions requested: 13 Jan 2009 Revisions received: 8 May 2009 Accepted: 18 Jun 2009 Published: 18 Jun 2009 Arthritis Research Therapy 2009, 11:R91 (doi:10.1186/ar2733) This article is online at: /content/11/3/R91 © 2009 Rossol et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Chemokines and their receptors control immune decreased disease susceptibility for carriers of the CCR5d32 cell migration during infections as well as in autoimmu