原创力文档nef-specific cd45ra+ cd8+ t cells secreting mip-1β but not ifn-γ are associated with nonprogressive hiv-1 infectionnef-specific cd45ra + cd8 + t细胞分泌mip-1β但不是ifn-γ与nonprogressive hiv - 1感染.pdfVIP
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nef-specificcd45racd8tcellssecretingmip-1βbutnotifn-γareassociatedwithnonprogressivehiv-1infectionnef-specificcd45racd8t细胞分泌mip-1β但不是ifn-γ与nonprogressivehiv-1感染
Dembek et al. AIDS Research and Therapy 2010, 7:20
/content/7/1/20
R E S E A R C H Open Access
Research
Nef-specific CD45RA+ CD8+ T cells secreting
MIP-1β but not IFN-γ are associated with
nonprogressive HIV-1 infection
1 1 4,5 2,9 7 6 6
Claudia J Dembek* , Sarah Kutscher , Silvia Heltai , Simone Allgayer , Priscilla Biswas , Silvia Ghezzi , Elisa Vicenzi ,
9 3 8 10 4 11
Dieter Hoffmann , Peter Reitmeir , Giuseppe Tambussi , Johannes R Bogner , Paolo Lusso , Hans-J Stellbrink ,
Elena Santagostino12, Thomas Vollbrecht10, Frank D Goebel10, Ulrike Protzer1,2,9, Rika Draenert10, Marco Tinelli13,
Guido Poli5,14, Volker Erfle1,2, Mauro Malnati†4 and Antonio Cosma*†1,2
Abstract
Background: Long-term survival of HIV-1 infected individuals is usually achieved by continuous administration of
combination antiretroviral therapy (ART). An exception to this scenario is represented by HIV-1 infected
nonprogressors (NP) which maintain relatively high circulating CD4+ T cells without clinical symptoms for several years
in the absence of ART. Several lines of evidence indicate an important role of the T-cell response in the modulation of
HIV-1 infection during the acute and chronic phase of the disease.
Results: We analyzed the functional and the differentiation phenotype of Nef- and Tat-specific CD8+ T cells in a cohort
of HIV-1 infected NP in comparison to progressors, ART-treated seropositive individuals and individuals undergoing a
single cycle of ART interruption. We observed that a distinctive feature of NP is the presence of Ne
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