multiple stimuli-responsive hydrogels for metal-based drug therapy使用多个stimuli-responsive水凝胶金属药物治疗.pdfVIP

Polymers 2012, 4, 964-985; doi:10.3390/polym4020964 OPEN ACCESS polymers ISSN 2073-4360 /journal/polymers Article Multiple Stimuli-Responsive Hydrogels for Metal-Based Drug Therapy Mario Casolaro * and Ilaria Casolaro Department of Pharmaceutical and Applied Chemistry, University of Siena, Via A. Moro 2, I-53100 Siena, Italy; E-Mail: casolaro@unisi.it * Author to whom correspondence should be addressed; E-Mail: mario.casolaro@unisi.it; Tel.: +39-0577-234-388; Fax: +39-0577-234-177. Received: 31 January 2012; in revised form: 15 March 2012 / Accepted: 20 March 2012 / Published: 27 March 2012 Abstract: A series of homopolymeric and copolymeric hydrogels containing the N-isopropylacrylamide and vinyl monomers with α-amino acid (L-valine and L-phenylalanine) residues have been synthesized and their swelling properties were evaluated under different external stimulations. The hydrogels, obtained with different cross-linking agents (EBA and PEG-DA), have shown unique properties such as biocompatibility in addition to the stimuli-responsive characters. These ‘smart’ hydrogels exhibit single or multiple stimuli-responsiveness which could be used in biomedical applications, including controlled drug delivery. This article focuses on recent developments dealing with the delivery of metal-based drug (cisplatin, lithium) from the stimuli-responsive hydrogels proposed as platforms for cancer and bipolar dis