原创力文档multiple distinct small rnas originate from the same microrna precursors多个不同的小分子rna源自相同的微rna前体.pdfVIP
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multiple distinct small rnas originate from the same microrna precursors多个不同的小分子rna源自相同的微rna前体
Zhang et al. Genome Biology 2010, 11:R81
/2010/11/8/R81
RESEARCH Open Access
Multiple distinct small RNAs originate from the
same microRNA precursors
1,2*† 3† 1 1 3 1
Weixiong Zhang , Shang Gao , Xuefeng Zhou , Jing Xia , Padmanabhan Chellappan , Xiang Zhou ,
3 3*
Xiaoming Zhang , Hailing Jin
Abstract
Background: MicroRNAs (miRNAs), which originate from precursor transcripts with stem-loop structures, are
essential gene expression regulators in eukaryotes.
Results: We report 19 miRNA precursors in Arabidopsis that can yield multiple distinct miRNA-like RNAs in addition
to miRNAs and miRNA*s. These miRNA precursor-derived miRNA-like RNAs are often arranged in phase and form
duplexes with an approximately two-nucleotide 3’-end overhang. Their production depends on the same
biogenesis pathway as their sibling miRNAs and does not require RNA-dependent RNA polymerases or RNA
polymerase IV. These miRNA-like RNAs are methylated, and many of them are associated with Argonaute proteins.
Some of the miRNA-like RNAs are differentially expressed in response to bacterial challenges, and some are more
abundant than the cognate miRNAs. Computational and expression analyses demonstrate that some of these
miRNA-like RNAs are potentially functional and they target protein-coding genes for silencing. The function of
some of these miRNA-like RNAs was further supported by their target cleavage products from the published small
RNA degradome data. Our systematic examination of public small-RNA deep sequencing data from four additional
plant species (Oryza sativa, Physcomitrella patens, Medicago truncatula and Populus trichocarpa) and four animals
(Homo sapiens, Mus mus
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