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Available online /content/9/S1/S4 Review Multiple myeloma/hypercalcemia Babatunde O Oyajobi University of Texas Health Science Center at San Antonio, Department of Cellular and Structural Biology (MSC 7762), Floyd Curl Drive, San Antonio, Texas 78229-3900, USA Correspondence: Babatunde O Oyajobi, oyajobi@ Published: 29 June 2007 Arthritis Research Therapy 2007, 9(Suppl 1):S4 (doi:10.1186/ar2168) This article is online at /content/9/S1/S4 © 2007 BioMed Central Ltd Abstract problem for which there is no effective cure. Hypercalcemia, Multiple myeloma, a cancer of plasma cells, is associated with which can range in presentation from mild to severe and life excessive tumor-induced, osteoclast-mediated bone destruction. threatening, is the most common metabolic complication of Hypercalcemia remains the most frequent metabolic complication myeloma and occurs in approximately one-third of patients. of myeloma in patients, and excessive osteolysis plays a major contributory role in its pathogenesis. The clinical presentation of Hypercalcemia in myeloma hypercalcemia in patients varies depending on the level of ionized In myeloma patients, the primary cause of the hypercalcemia is calcium; it can be life threatening, as in the case of hypercalcemic crisis, requiring immediate medical treatment to prevent death. widespread tumor-induced bone destruction. This is primarily During the past few years there have been exciting developments due to increased osteoclastic bone resorption