multiple sequence alignment with user-defined anchor points多重序列比对与用户定义的锚点.pdfVIP

Algorithms for Molecular Biology BioMed Central Research Open Access Multiple sequence alignment with user-defined anchor points 1 2 1 2 Burkhard Morgenstern* , Sonja J Prohaska , Dirk Pöhler and Peter F Stadler Address: 1Universität Göttingen, Institut für Mikrobiologie und Genetik, Abteilung für Bioinformatik, Goldschmidtstrasse. 1, D-37077 Göttingen, Germany and 2Universität Leipzig, Institut für Informatik und Interdisziplinäres Zentrum für Bioinformatik, Kreuzstrasse 7b, D-04103 Leipzig, Germany Email: Burkhard Morgenstern* - burkhard@gobics.de; Sonja J Prohaska - sonja@bioinf.uni-leipzig.de; Dirk Pöhler - dpoehler@math.uni- goettingen.de; Peter F Stadler - Peter.Stadler@bioinf.uni-leipzig.de * Corresponding author Published: 19 April 2006 Received: 15 February 2006 Accepted: 19 April 2006 Algorithms for Molecular Biology 2006, 1:6 doi:10.1186/1748-7188-1-6 This article is available from: /content/1/1/6 © 2006 Morgenstern et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Automated software tools for multiple alignment often fail to produce biologically meaningful results. In such situations, expert knowledge can help to improve the quality of alignments. Results: Herein, we describe a semi-automatic version of th