new triterpene saponins from duranta repens linn. and their cytotoxic activity新三萜皂苷duranta被林。.pdfVIP

Molecules 2009, 14, 1952-1965; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity Wafaa S. Ahmed 1, Mona A. Mohamed 1,*, Rabab A. El-Dib 2 and Manal M. Hamed 1 1 Department of Medicinal Chemistry, Theodor Bilharz Research Institute, P.O.B. 12411, Giza, Egypt; E-mails: eb2003 eg@ (W-S.A), manalayman@ (M-M.H.) - 2 Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, P.O.B. 11795, Ain- Helwan, Cairo, Egypt; E-mail: reldib@ (R-A.E-D.) * Author to whom correspondence should be addressed; E-mail: tbyahoo.co.uk; Fax: +20233388801 Received: 29 March 2009; in revised form: 8 May 2009 / Accepted: 13 May 2009 / Published: 25 May 2009 Abstract: From the leaves of Duranta repens (Verbenaceae) two new triterpene saponins, named durantanin IV (1) and V (2) were isolated. In addition, ten known compounds were isolated, namely a bidesmosidic saponin, oleanolic acid, three phenylethanoids and five flavonoids. All metabolites were isolated for the first time from this genus except for 3 (oleanolic acid) and 7 (E/Z acteoside). The structures were determined mainly by 1 13 1 1 spectroscopic methods (UV, IR, HRESI-MS, H-, C-NMR, H- H COSY, HSQC and HMBC). Cytotoxic screening of the chloroform, ethyl ac