原创力文档natural selection of protein structural and functional properties a single nucleotide polymorphism perspective自然选择的蛋白质结构和功能属性单核苷酸多态性的角度来看.pdfVIP
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natural selection of protein structural and functional properties a single nucleotide polymorphism perspective自然选择的蛋白质结构和功能属性单核苷酸多态性的角度来看
Volume 9, Issue 4, Article R69et al.Liu2008 Open Access
Research
Natural selection of protein structural and functional properties: a
single nucleotide polymorphism perspective
* * † *
Jinfeng Liu , Yan Zhang , Xingye Lei and Zemin Zhang
Addresses: *Department of Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. †Department of Biostatistics,
Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Correspondence: Zemin Zhang. Email: zemin@
Published: 8 April 2008 Received: 20 March 2008
Revised: 25 March 2008
Genome Biology 2008, 9:R69 (doi:10.1186/gb-2008-9-4-r69)
Accepted: 8 April 2008
The electronic version of this article is the complete one and can be
found online at /2008/9/4/R69
© 2008 Liu et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which
permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Measure of selective constraintsstraints on human proteins of different structural and functional categories./ppA large-scale survey using single nucleotide polymorphism data from dbSNP provides insights into the evolutionary selection con-
Abstract
Background: The rates of molecular evolution for protein-coding genes depend on the stringency
of functional or structural constraints. The Ka/Ks ratio has been commonly used as an indicator of
selective cons
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