原创力文档natural variation in dna methylation in ribosomal rna genes of arabidopsis thaliana自然变异在核糖体rna基因的dna甲基化的拟南芥.pdfVIP
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natural variation in dna methylation in ribosomal rna genes of arabidopsis thaliana自然变异在核糖体rna基因的dna甲基化的拟南芥
BMC Plant Biology BioMed Central
Research article Open Access
Natural variation in DNA methylation in ribosomal RNA genes of
Arabidopsis thaliana
Hye Ryun Woo and Eric J Richards*
Address: Department of Biology, Washington University, One Brookings Drive, St. Louis, MO 63130, USA
Email: Hye Ryun Woo - hrwoo@; Eric J Richards* - richards@
* Corresponding author
Published: 10 September 2008 Received: 30 June 2008
Accepted: 10 September 2008
BMC Plant Biology 2008, 8:92 doi:10.1186/1471-2229-8-92
This article is available from: /1471-2229/8/92
© 2008 Woo and Richards; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: DNA methylation is an important biochemical mark that silences repetitive
sequences, such as transposons, and reinforces epigenetic gene expression states. An important
class of repetitive genes under epigenetic control in eukaryotic genomes encodes ribosomal RNA
(rRNA) transcripts. The ribosomal genes coding for the 45S rRNA precursor of the three largest
eukaryotic ribosomal RNAs (18S, 5.8S, and 25–28S) are found in nucleolus organizer regions
(NORs), comprised of hundreds to thousands of repeats, only some of which are expressed in any
given cell. An epigenetic swit
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