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Molecules 2012, 17, 4028-4036; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Naucline, a New Indole Alkaloid from the Bark of Nauclea officinalis † Sook Yee Liew 1, Mat Ropi Mukhtar 1, A. Hamid A. Hadi 1, Khalijah Awang 1,*, 2 3 3 4 Mohd Rais Mustafa , Kazumasa Zaima , Hiroshi Morita and Marc Litaudon 1 Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia; E-Mails: joeyliew5382@.my (S.Y.L.); ahamid@.my (A.H.A.H.) 2 Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; E-Mail: rais@.my 3 Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan; E-Mail: moritah@hoshi.ac.jp 4 Institut de Chimie de la Substances Naturelles, Centre Nationale de la Recherches Scientifique, 91198, Gif-sur Yvette, Cedex, France; E-Mail: marc.litaudon@rs-gif.fr † We wish to dedicate this article to our dearest colleague, Dr. Mat Ropi bin Mukhtar who has been a great inspiration to natural product research in Malaysia and globally. * Author to whom correspondence should be addressed; E-Mail: khalijah@.my; Tel.: +603-7967-4064; Fax: +603-7967-4193. Received: 9 February 2012; in revised form: 27 March 2012 / Accepted: 28 March 2012 / Published: 2 April 2012 Abstract: A new indole alkaloid, naucline (1) together with four known alkaloids, angustine (2), angusti