原创力文档natural gums as sustained release carriers development of gastroretentive drug delivery system of ziprasidone hcl自然牙龈持续释放运营商发展gastroretentive盐酸齐拉西酮的药物输送系统.pdfVIP
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natural gums as sustained release carriers development of gastroretentive drug delivery system of ziprasidone hcl自然牙龈持续释放运营商发展gastroretentive盐酸齐拉西酮的药物输送系统
AJ et al. DARU Journal of Pharmaceutical Sciences 2012, 20:58
/content/20/1/58
RESEARCH ARTICLE Open Access
Natural gums as sustained release carriers:
development of gastroretentive drug delivery
system of ziprasidone HCl
1 2 2*
Rajamma AJ , Yogesha HN and Sateesha SB
Abstract
Background: Objective of this study is to show the potential use of natural gums in the development of drug
delivery systems. Therefore in this work gastro retentive tablet formulations of ziprasidone HCl were developed
using simplex lattice design considering concentration of okra gum, locust bean gum and HPMC K4M as
independent variables. A response surface plot and multiple regression equations were used to evaluate the effect
of independent variables on hardness, flag time, floating time and drug release for 1 h, 2 h, and 8 h and for 24 h. A
checkpoint batch was also prepared by considering the constraints and desirability of optimized formulation to
improve its in vitro performance. Significance of result was analyzed using ANOVA and p 0.05 was considered
statistically significant.
Results: Formulation chiefly contains locust bean gum found to be favorable for hardness and floatability but
combined effect of three variables was responsible for the sustained release of drug. The in vitro drug release data
of check point batch (F8) was found to be sustained well compared to the most satisfactory formulation (F7) of 7
runs. The ‘n’ value was found to be between 0.5 and 1 suggesting that release of drug follows anomalous (non-
fickian) diffusion mechanism indicating both diffusion and erosion mechanism from these natural gums. Predicted
results were almost similar to the observed experimental values indicating the accuracy of the design. In vivo
floatability test indicated n
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