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Materials 2011, 4, 1818-1834; doi:10.3390/ma4101818 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Article Multi-Echo-Based Echo-Planar Spectroscopic Imaging Using a 3T MRI Scanner Jon K. Furuyama , Brian L. Burns , Neil E. Wilson and M. Albert Thomas Department of Radiological Sciences, University of California, Los Angeles, CA 90095, USA Medical Imaging Informatics (MII) Lab, University of California, Los Angeles, CA 90095, USA Author to whom correspondence should be addressed; E-Mail: AThomas@. Received: 2 September 2011; in revised form: 6 October 2011 / Accepted: 7 October 2011 / Published: 17 October 2011 Abstract: The use of spin-echoes has been employed in an Echo-Planar Spectroscopic Imaging (EPSI) sequence to collect multiple phase encoded lines within a single TR in a Multi-Echo-based Echo-Planar Spectroscopic Imaging technique (MEEPSI). Despite the dependence on the amplitude of the spin-echoes, the Full Width at Half Maximum (FWHM) of the derived multi-echo Point Spread Function (PSF) is shown to decrease, indicating an improved overall spatial resolution without requiring any additional scan time. The improved spatial resolution is demonstrated in the one-dimensional (1D) spatial profiles of the N-Acetyl Aspartate (NAA) singlet along the phase encode dimension in a gray matter phantom. Although the improved spatial resolution comes at the expense of spectral resolution, it is shown in vivo that peak broadening due to decay is more significant than