原创力文档nutriomes and nutrient arrays - the key to personalised nutrition for dna damage prevention and cancer growth controlnutriomes个性化的营养和养分数组u2014u2014关键dna损伤预防和控制肿瘤生长.pdfVIP
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nutriomes and nutrient arrays - the key to personalised nutrition for dna damage prevention and cancer growth controlnutriomes个性化的营养和养分数组u2014u2014关键dna损伤预防和控制肿瘤生长
Fenech Genome Integrity 2010, 1:11
/content/1/1/11 GENOME INTEGRITY
REVIEW Open Access
Nutriomes and nutrient arrays - the key to
personalised nutrition for DNA damage
prevention and cancer growth control
Michael F Fenech
Abstract
DNA damage at the base-sequence, epigenome and chromosome level is a fundamental cause of developmental
and degenerative diseases. Multiple micronutrients and their interactions with the inherited and/or acquired gen-
ome determine DNA damage and genomic instability rates. The challenge is to identify for each individual the
combination of micronutrients and their doses (i.e. the nutriome) that optimises genome stability and DNA repair.
In this paper I describe and propose the use of high-throughput nutrient array systems with high content analysis
diagnostics of DNA damage, cell death and cell growth for defining, on an individual basis, the optimal nutriome
for DNA damage prevention and cancer growth control.
Background and Current Status term culture of cells (e.g. stem cells) which may be
DNA damage at the base sequence, epigenome and taken out of the body for expansion and then returned
chromosome level is the most fundamental cause of to the original donor or other recipients for medical
developmental and degenerative diseases (including therapy reasons because DNA damage accumulated
accelerated ageing) and is predictive prospectively of in vitro may result in oncogenic events in stem cells
these conditions [1-3]. Hundreds of genes are involved [29,30]. Currently dietary reference values (e.g. recom-
in maintenance of genome integrity and there is great mended dai
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