osteoimmunology in rheumatic diseases近年来在风湿性疾病.pdfVIP

Available online /content/11/1/210 Review Osteoimmunology in rheumatic diseases Georg Schett Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany Corresponding author: Georg Schett, georg.schett@uk-erlangen.de Published: 30 January 2009 Arthritis Research Therapy 2009, 11:210 (doi:10.1186/ar2571) This article is online at /content/11/1/210 © 2009 BioMed Central Ltd Abstract Current concepts of osteoimmunology This review summarizes the recent advances of osteoimmunology, Osteoimmunology is one of the areas that allow investigators to a new research field that investigates the interaction of the immune gain novel insights into the crosstalk between the immune and system with the skeleton. Osteoimmunology has contributed signifi- the musculoskeletal systems [1]. This field of research is par- cantly to the understanding of joint destruction in rheumatoid arthritis ticularly relevant to the understanding of rheumatic diseases, and other forms of arthropathies. In particular, the molecular regula- which are characterized by profound alterations of bone tion of osteoclast formation and its control by proinflammatory architecture aside from immune activation. The term osteo- cytokines have helped investigators to understand the mechanisms of bone erosion in rheumatic diseases. Osteoimmunology has also immunology is a rather novel one. It was created in the late allowed an improvement in our knowledge of the structure-sparing 1990s after landmark observations